Question: Map genetic mutations to protein domain or structure with a higher resolution than UniProt
gravatar for ejoffe
3.3 years ago by
ejoffe10 wrote:

I would like to map genomic alterations and their associated amino acid changes to the structural domains of the affected proteins.

For example, for mutations in TP53 I would like to know if a protein change is in the L3, L2 or LSH helix motif of the DNA binding domain or somewhere else.

From what I see on UniProt it only gives a higher level domain location (e.g. in the TP53 it specifies whether the change is in the DNA binding domain but doesn't give further information about the specific locations).

Is there any tool that I could use or I just have to do a manual literature search for each protein change ?

Thank you, E

p.s. - link to a similar question (but different ....) Map genetic mutations to protein domain/structure

blast snp next-gen R genome • 1.3k views
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