I am planning to perform DNA seq for detection of aneluploidy condition in circulatory DNA. Is there a set rule how much sequencing depth should be used. Secondly I read few papers but could not find a set software to detect aneluploidy from DNA sequencing. Is there a set software or tool that can be useful. Any suggestion will be helpful. I am working with human genome and using Illumina nex seq platform for whole genome DNA seq.