Question: can a rank based inverse normal transformation of a continuous trait affect the significance/power
0
gravatar for muralinmars
4.0 years ago by
muralinmars80
France
muralinmars80 wrote:

Hi,

I have this question from the recent analysis that I have been doing.

I am meta-analysing a continous trait (say TRAIT1), that is inverse normal transformed. And one particular locus that was GW significant in an earlier effort (using log-transformed values) completely loses its significance in the current analysis.

The sample size is more or less the same.

Here is a paper that suggests Inverse normal transformation can reduce power in few instances.

Is this possible!

Thanks in advance. M

gwas • 1.4k views
ADD COMMENTlink modified 4.0 years ago • written 4.0 years ago by muralinmars80
Please log in to add an answer.

Help
Access

Use of this site constitutes acceptance of our User Agreement and Privacy Policy.
Powered by Biostar version 2.3.0
Traffic: 974 users visited in the last hour
_