I have ~200 exomes which includes related and unrelated individuals. I have done the joint genotype calling and calculated the allele frequency using VCFtools. But as its a mixed population what is the ideal way to calculate allele frequency?. I would like to make an in-house variant database from our available exomes and the corresponding allele frequencies will be used to filter the variants. It would be helpful if you can give some further information about the methods to adjust relatedness. Thank you ..
Question: Allele frequency calculation
3.1 years ago by
nkausthu • 20
nkausthu • 20 wrote:
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