Question: Does MACS2 or MACS14 perform total reads normalization?
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gravatar for bxia
13 months ago by
bxia120
bxia120 wrote:

Does MACS2 or MACS14 perform total reads normalization?

I didn't see them to discuss about it. Just want to make sure the default parameters doesn't do the total reads normalization.

Thanks,

chip-seq • 457 views
ADD COMMENTlink modified 13 months ago by Biostar ♦♦ 20 • written 13 months ago by bxia120
1

The chip and control reads are scaled to same sequencing depth ( towards lower ) before doing a poisson test for signal enrichment.

ADD REPLYlink written 13 months ago by geek_y8.3k
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