Question: Does MACS2 or MACS14 perform total reads normalization?
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gravatar for bxia
4 months ago by
bxia90
bxia90 wrote:

Does MACS2 or MACS14 perform total reads normalization?

I didn't see them to discuss about it. Just want to make sure the default parameters doesn't do the total reads normalization.

Thanks,

chip-seq • 199 views
ADD COMMENTlink modified 4 months ago by Biostar ♦♦ 20 • written 4 months ago by bxia90
1

The chip and control reads are scaled to same sequencing depth ( towards lower ) before doing a poisson test for signal enrichment.

ADD REPLYlink written 4 months ago by Goutham Atla7.2k
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