How to merge 24 ESP vcf files into one?

Question

[agicict]

Hi

I downloaded Exome-seq project's vcf files from below site and would like to merge them into one. (http://evs.gs.washington.edu/EVS/)

I searched tools for merging vcf files but I am facing errors.

In addition, I need to append 'chr' to chromosome since ESP vcfs have no 'chr' prefix.

How to solve this issue?

[st.ph.n]

I searched tools for merging vcf files but I am facing errors.

What tools did you try? And what errors did you get?

Did you look into VCFtools?

Answer 1

[theobroma22]

See this previous post to merge in R: C: Merging of datasets from same tissue/region

To append "chr" to a vector of names called ID in a dataframe stored as a df object in R you can use:

paste0("chr_" , df$ID)

[Pierre Lindenbaum]

sed