Question: subcellular localization human / Mouse / Rat
gravatar for bzhtgb
4 days ago by
bzhtgb10 wrote:

Hi all, I try to annotate subcellular localization for all human, rat, mouse proteins. My goal is to add clear and simple information to manage (use a very limited vocabulary -example: secreted, transmembrane, cytosol, mitochondria, nucleus). I think I already performed a good annotation focused on secreted, using several db and papers. For the other localization, I'm going to look at eSLDB, LOCATE, comPPI.. Other possibility will be to used a predictor but ideally, I want to make a distinction between experimental evidence, prediction, inferred by homology, ... My goal is not to have a perfect thing at the end but to find easy sets of data to integrate, with a limited number of vocabulary/ cell compartment.

I know that is an old question, I find a similar post, with some good and usefull information but this post is 7 years olds.

Finally my question is , how do you manage localization in a simple way?


localization protein • 91 views
ADD COMMENTlink modified 1 day ago by Arnaud Ceol730 • written 4 days ago by bzhtgb10
gravatar for Elisabeth Gasteiger
1 day ago by
Elisabeth Gasteiger1.1k wrote:

Subcellular location information can be found in the UniProt Knowledgebase, in particular in the reviewed section UniProtKB/Swiss-Prot, as described in The controlled vocabulary used for this is available at (or, and evidence is provided where possible (

You can use the advanced search tool on the UniProt website to search by location and evidence.

ADD COMMENTlink written 1 day ago by Elisabeth Gasteiger1.1k
gravatar for Arnaud Ceol
1 day ago by
Arnaud Ceol730
Milan, Italy
Arnaud Ceol730 wrote:

You may check the Compartment database: (this is a Stringdb's style database for sub cellular compartments).

ADD COMMENTlink written 1 day ago by Arnaud Ceol730
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