Question: Gene Body methylation
0
gravatar for niutster
3.8 years ago by
niutster100
niutster100 wrote:

Hi,

Has gene body methylation effect on its expression? As i know GpG Islands, Shores and regions such as these have great effect on gene expression.

gene genome • 2.1k views
ADD COMMENTlink modified 3.8 years ago by EagleEye6.8k • written 3.8 years ago by niutster100
1
gravatar for EagleEye
3.8 years ago by
EagleEye6.8k
Sweden
EagleEye6.8k wrote:

This is an article where it shows gene body methylation has opposite effect on gene expression compared to promoter methylation.

Gene Body Methylation Can Alter Gene Expression and Is a Therapeutic Target in Cancer

This is the article where they show it in more systematic way.

ADD COMMENTlink modified 3.8 years ago • written 3.8 years ago by EagleEye6.8k
0
gravatar for Devon Ryan
3.8 years ago by
Devon Ryan98k
Freiburg, Germany
Devon Ryan98k wrote:

Yes, gene body methylation (at least in some cases) seems to stabilize transcription, thereby increasing expression.

ADD COMMENTlink written 3.8 years ago by Devon Ryan98k

So does it means that methylation can cause not only negative effect but also positive effect?

ADD REPLYlink written 3.8 years ago by zjhzwang180

Correct, promoter methylation will generally decrease expression while gene body methylation will generally increase it.

ADD REPLYlink written 3.8 years ago by Devon Ryan98k

does not it also refer to if the methylation is hyper or hypo? based on that the expression of the gene is more or less active or repressed?

ADD REPLYlink written 3.8 years ago by ivivek_ngs5.1k

In this context, "methylation" will always be "hypermethylation".

ADD REPLYlink written 3.8 years ago by Devon Ryan98k
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