Gene Body methylation
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4.5 years ago
niutster ▴ 100

Hi,

Has gene body methylation effect on its expression? As i know GpG Islands, Shores and regions such as these have great effect on gene expression.

genome gene • 2.2k views
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4.4 years ago
EagleEye 7.1k

This is an article where it shows gene body methylation has opposite effect on gene expression compared to promoter methylation.

Gene Body Methylation Can Alter Gene Expression and Is a Therapeutic Target in Cancer

This is the article where they show it in more systematic way.

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4.5 years ago

Yes, gene body methylation (at least in some cases) seems to stabilize transcription, thereby increasing expression.

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So does it means that methylation can cause not only negative effect but also positive effect?

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Correct, promoter methylation will generally decrease expression while gene body methylation will generally increase it.

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does not it also refer to if the methylation is hyper or hypo? based on that the expression of the gene is more or less active or repressed?

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In this context, "methylation" will always be "hypermethylation".

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