QTL mapping vs. Association mapping for bi-parental crosses

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6.9 years ago

Mat ▴ 60

I have got genotype data of ~200 F2 samples which where derived from two grandparents (F0) AA and BB, and intercrossed (AB x AB) parents in the F1 generation.

In order to detect loci that are associated with a continuous phenotype, typically, one performs a QTL mapping.

Does an additional association mapping (linear model) give any further information on QTLs or why or why not is association mapping not the right method for this data? I know that association mapping is normally used in GWAS where individuals are unrelated.

qtl mapping • 2.4k views

ADD COMMENT • link 6.9 years ago by Mat ▴ 60

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Hi Matthias,

I suspect this old post will give you a lot of the info. you need. If it does not, I will try to provide any further answers you require: Gwas Vs. Qtl Mapping?

ADD REPLY • link 6.9 years ago by LauferVA 4.2k

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Hi Vincent, I know this post already. However, my questions are not answered by it. Maybe you can add some information here?

ADD REPLY • link 6.9 years ago by Mat ▴ 60

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