Question: Produce Multiple Sequence Alignments using Profile HMMs
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3.3 years ago by
bordieszter0 wrote:

I have a few multiple sequence alignments and a few groups (let's say N) of unaligned sequences. I would like to learn the emission and transition probabilities from the multiple sequence alignments, to build with these distributions a profile HMM and then to produce with the Viterbi algorithm N multiple sequence alignments from the groups of unaligned sequences.

I have a known profile HMM structure, I have a Viterbi implementation but I am having trouble figuring out how to estimate emission distributions and transition distributions from the available multiple sequence alignments. Any ideas?

learn msa hmm viterbi baum-welch • 813 views
ADD COMMENTlink written 3.3 years ago by bordieszter0
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