Question: MiRNA orthologues between human and chick
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gravatar for fana
3.8 years ago by
fana30
London
fana30 wrote:

I am trying to find miRNA ortholgues between human and chick. Is it valid to say that the ones with exactly the same name are ortholgues? For example, hsa-let-7a-2-3p and gga-let-7a-2-3p.

mirna microrna orthologues • 909 views
ADD COMMENTlink modified 3.6 years ago by Biostar ♦♦ 20 • written 3.8 years ago by fana30

I would call them "conserved" more than orthologues, I THINK it is more appropriate.

ADD REPLYlink written 3.8 years ago by Buffo1.8k

By definition orthologs are genes whose last common ancestor was a speciation event. You can't infer this from gene names or even just aligning two sequences. You need a phylogenetic tree. It could be that the genes were named the same because a phylogenetic tree shows them to be orthologous but you need to verify this before concluding that they are orthologs because they have the same name.

ADD REPLYlink written 3.8 years ago by Jean-Karim Heriche24k
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