I have 2 patients, each of which has normal, primary, and metastatic samples whole exome sequenced. If I compare somatic mutations in primary and metastatic samples Patient 1: N_somatic_mutations_primary N_somatic_mutations_metastatic N_intersection 532 778 132
Patient 2: primary sample has even more somatic mutations than metastatic sample.
Ideally, all somatic mutations in primary should be included in metastatic from same patient. There can be errors, and we could be missing some mutations.
What can I do with this data?