software recommendations for identifying self from non-self dna sequences
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7.0 years ago
bitpir ▴ 240

Hi there, I'm just wondering if there's a software out there that could help with identifying self from non-self dna sequences. I have the whole genome/wex dna sequences from an individual (self), and I also have a mixture of dna samples containing self and non-self (other individuals) samples. My goal is to figure out how much self is there from the pool of dna mixture. I've been trying to use Mutect/Mutect2, setting self as normal and tumor as non-self. However, it seems (and please correct me if I'm wrong) like the final output is vcf, which is less informative in figuring out the proportions of sequences mapping to self vs non-self. Any suggestion on how to better analyze this? Thanks!

forensics dna sequencing • 987 views
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