Question: Correlation for meta-analysis assessing inter-platform reliability
gravatar for ab123
2.2 years ago by
ab12340 wrote:

Hey there,

I'm a tad confused as to the best method to assess platform reliability after conducting a meta-analysis.

I've run both Pearson correlations on 50 common top genes across logFCs from all included data sets in a meta analysis as well as Bland-Altman. I understand that they assess very different things.

There are various conflicting studies on this with some using correlation to discuss agreement between microarray platforms and others the B-A.

The other confusing issue for me is whether I need them at all. If I'm assessing the top 50 genes or say even all of them from a meta analysis, can I truly talk about platform agreement here? Isn't biological sample variation and therefore measurement variation to be expected?

Thanks for any insights, pointers etc.!

ADD COMMENTlink modified 2.1 years ago by Biostar ♦♦ 20 • written 2.2 years ago by ab12340
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