Reinterpreting variant results in an EHR

Question

[bdolin]

Greetings,

I'm wondering if anyone can point me to references that discuss challenges with reinterpreting variant results in an EHR.

There are (at least) two reinterpretation scenarios I'm trying to better understand:

1. New findings come out, prompting a re-examination of existing variants;

2. A clinician is about to prescribe a new drug, and wants to direct the re-examination of existing data for an interacting genotype.

Thanks