SIGNATURE MATRIX IN CIBERSORT
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4.5 years ago

Does anyone know of other cell type signatures besides LM22 from CIBERSORT? I am working with CIBERSORT but I have a lots problems due to different probes from mixture w.r.t. LM22. I mean LM22 takes care and find out cell lines like B cells naive, B cells memory, Plasma cells, T cells CD8, T cells CD4 naive. I am working with a mixtures dataset composed by cell lines like FFA-ABC-E6, FFA-ABC-C6, FFA-GCB-A6 FFA-GCB-D2. How can I use CIBERSORT? How can I generate new signature matrix or manipulate LM22 in order to make it fit to my problem and analysis? I found this error when I am trying to run CIBERSORT: No overlap in genes between the mixture and signature genes files found. Thank you for your disponibility

RNA-Seq software error gene • 4.5k views
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13 months ago
dare_devil ★ 1.5k

Go through this paper . They mention about creating custom signature matrix

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