bioinformatics metagenomics analysis towards finding drug candidates

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6.7 years ago

Quak ▴ 490

I wonder what are the possibilities towards finding drug/metabolite candidates using metagenomics data. Metagenomics data only provides prokaryotic related data (well, there would be some host genome as well), I wonder what are the possibility to study host-metagenome interaction towards finding drug/metabolite candidates.

metagenomics • 1.3k views

ADD COMMENT • link updated 6.6 years ago by Biostar 20 • written 6.7 years ago by Quak ▴ 490

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Don't wonder, search.

Some potentially helpful reviews:

https://www.ncbi.nlm.nih.gov/pubmed/25614221

https://www.ncbi.nlm.nih.gov/pubmed/26791724

https://www.ncbi.nlm.nih.gov/pubmed/26379658

https://www.ncbi.nlm.nih.gov/pubmed/19903165

ADD REPLY • link 6.7 years ago by h.mon 35k

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Thanks for sharing these links and sorry for not making it clear. I am more curious about the computational approaches on this matter rather than experimental efforts. e.g from geneX, in KEGG database, what are the reasonable practices one can take to generate a list of metabolite/protein candidates. How can I take the Gene sequence, look it up and see what enzyme/protein are transcribed. The same regarding metabolites.

ADD REPLY • link 6.7 years ago by Quak ▴ 490

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