Future direction of Gene Set Enrichment Analysis
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5.3 years ago
lmanohara99 ▴ 20

Gene Set Enrichment analysis has a quite developed method in the recent past. But existing methods can have pitfalls. I would like to research on GSEA and I need to to know what would be the future direction of this research area.

RNA-Seq gene GSEA • 1.8k views
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Sidebar: I think GSEA should be reserved for this method: http://software.broadinstitute.org/gsea/index.jsp

Do others agree? Disagree?

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5.3 years ago
The ▴ 180

One important point is correlation between gene expression so independence assumption doesn't hold true. Some methods addressed this issue

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3458527/

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5.3 years ago
lmanohara99 ▴ 20

Can we take a machine learning based approach for solving the same problem which has been solved by the statistical methods?

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