Question: Level of selection
0
gravatar for ibasan
21 months ago by
ibasan40
ibasan40 wrote:

Dear community,

i performed codon based z-test for two genes to compare selective constraints between species groups ( purifying selection (dN < dS) as alternative hypotheses to the null hypotheses of strict neutrality (dN = dS)). Now i have Z statistic values which are slightly different between the groups. See example

                  Z statistic   p value
 gene A    group 1  3.262         0.001
           group 2  2.964         0.002

 gene B    group 1  3.062         0.005
           group 2  4.964         0.001

My question regards the strength of selection constraints acting on the different groups. Is it that in group 1 for gene A selection acts stronger? When we compare ka/ks ratios, i know that lower values would indicate stronger selection, like in this example for Group 2:

Gene A      ka/ks          p value
Group1      0.033     <0.001
Group2      0.027     <0.001

I am happy about any help!

ADD COMMENTlink written 21 months ago by ibasan40
Please log in to add an answer.

Help
Access

Use of this site constitutes acceptance of our User Agreement and Privacy Policy.
Powered by Biostar version 2.3.0
Traffic: 729 users visited in the last hour