Question: adj p-value for meta-analysis
0
gravatar for Edalat
3.3 years ago by
Edalat30
Edalat30 wrote:

I did meta-analysis by metaRNAseq package,it used adj p-value( method="BH"),should I convert adj p-value to fdr adj p-value or not? if yes,what package do you suggest?

ADD COMMENTlink modified 3.3 years ago by ATpoint42k • written 3.3 years ago by Edalat30
1

If it used BH it is already FDR. You can give a look at the documentation of p.adjust here

ADD REPLYlink written 3.3 years ago by Fabio Marroni2.6k

I don't understand the question. You get a FDR adjusted p out of your pipeline, so why further converting it?

ADD REPLYlink written 3.3 years ago by ATpoint42k

no,I got adjusted p-value. I mean should I convert them to FDR adj p-value for high accuracy?or adjusted p-value have high accuracy?

ADD REPLYlink written 3.3 years ago by Edalat30
1
gravatar for ATpoint
3.3 years ago by
ATpoint42k
Germany
ATpoint42k wrote:

What you think are two different values are actually the same thing. Use the p value that you already have. It has already been adjusted for FDR by BH, stands for Benjamini Hochberg method for false discovery rate adjustment. You are fine.

ADD COMMENTlink written 3.3 years ago by ATpoint42k
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