Question: detection of somatic mutations using RNA seq data for tumor samples paired with WES data for normal samples
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14 months ago by
sara.younes20
sara.younes20 wrote:

i have WES data for normal and I have RNA seq only for tumor. I want to use the RNA seq data to detect somatic driver mutations and I want to pair it with the normal WES data in order to be able to effectively filter the false positive somatic mutations. Is there a way to do that ? I have read a few method papers that use RNA seq for detection of somatic mutations but it is either that the RNA seq has paired normal and tumor samples or the others use unpaired RNA seq data to detect somatic mutations but I haven't found any paper which paired tumor and normal samples using RNA seq and WES data so I don't know if thats possible or not.

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