Question: Hyperbolic significance threshold for volcano plot
gravatar for Alejandro Jimenez Sanchez
10 days ago by
Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK


I was wondering if anyone has an idea of how to generate an "statistically" meaningful hyperbolic function that could be used as significance threshold for volcanos plots.

I have seen examples here and here in proteomics, and a colleague has the method for t-test in his PhD thesis but I wonder if it is possible to generalize it for other "tests" like wilcoxon and welch's.

I think it would be nice if that such application was more available and developed outside the proteomics field and t-tests.

volcanoplot • 94 views
ADD COMMENTlink modified 10 days ago • written 10 days ago by Alejandro Jimenez Sanchez100

It looks like it would have utility in many parts of biological science research, primarily RNA-seq, obviously. Currently, the cut-off for statistical significance in such experiments is mostly chosen manually. I guess this means that you should develop this further in your group in Cambridge? :)

ADD REPLYlink written 8 days ago by Kevin Blighe1.2k
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