"The impact of rare variation on gene expression across tissues" Nature 550, 239–243 (12 October 2017) doi:10.1038/nature24267
As far as I understand, using the GTex data, the authors have written a predictive algorithm (RIVER) to predict the consequences on gene expression of a set of variants.
Can you please explain me the Figure 5c. "Performance of RIVER for prioritizing functional regulatory variants. "
Distribution of RIVER scores (shades of blue) as a function of expression and genomic annotation scores. The distributions of variant categories across expression and genomic annotation scores are shown as histograms aligned opposite the corresponding axes.
I don't understand how I should read that figure ? What is the Y axis ? Whare are the red/oranges circles in the figure ?