Hi, I am working on the CCLE cell line mutation data. The mutation data is a summarized list, with each line representing a specific mutation in specific cell as well as other annotations including:
Hugo_Symbol Entrez_Gene_Id NCBI_Build Chromosome Start_position End_position Strand Variant_Classification Variant_Type Reference_Allele Tumor_Seq_Allele1 dbSNP_RS dbSNP_Val_Status Genome_Change Annotation_Transcript Tumor_Sample_Barcode cDNA_Change Codon_Change Protein_Change isDeleterious isTCGAhotspot TCGAhsCnt isCOSMIChotspot COSMIChsCnt ExAC_AF WES_AC WGS_AC SangerWES_AC SangerRecalibWES_AC RNAseq_AC HC_AC RD_AC
now I want to give a binary value or a probability score to denote whether a mutation is driver in this specific cell. I have checked many post and papers, but their method are all based on original sequencing data rather that such a mutation list. Any idea about how to do this? Many thanks in advance!