Question: Transmembrane domain protein structure
0
gravatar for YaGalbi
3.0 years ago by
YaGalbi1.5k
Biocomputing, MRC Harwell Institute, Oxford, UK
YaGalbi1.5k wrote:

Hello all,

I need advice regarding the best tool for predicting transmembrane domain structure. I know transmembrane domain structures are a difficult niche. We have mutated a single position in a transmembrane domain that has produced a phenotype. We suspect the mutation is preventing binding with another protein within the transmembrane. We want to know the effect of the mutation on the structure of the protein's transmembrane domain.

I have experience with Modeller and SwissModel, however, this was over a year ago and I was wondering is there more appropriate or better tools for this job. Is it simply a matter of tool preference or is there a clear best practice tool?

The protein is highly conserved, with structures in the PDB, however the structures do NOT include the transmembrane domain.

Regards

Kenneth

ADD COMMENTlink modified 3.0 years ago by cdsouthan1.8k • written 3.0 years ago by YaGalbi1.5k
0
gravatar for cdsouthan
3.0 years ago by
cdsouthan1.8k
cdsouthan1.8k wrote:

InterPro - but the unintegrated signatures at the bottom

ADD COMMENTlink written 3.0 years ago by cdsouthan1.8k
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