Question: tool for simulating genomes based on observed mutations?
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gravatar for ramiroricardo
20 months ago by
ramiroricardo0 wrote:

I have sequenced a set of bacterial clones, derived from the same reference strain, and identified a few thousand mutations. Sometimes I have more than one mutation in the same gene and I would like to know whether those cases are expected or not, given a random distribution of mutations.

I was thinking that I could do this by simulating genomes of my reference strain with mutations following the same mutation spectrum as the one I have in my vcf file. Does anyone know of a tool that can achieve this?

ADD COMMENTlink written 20 months ago by ramiroricardo0
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