Data set with both genetic variants and gene expressions
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6.4 years ago

Hi there,

as it seems getting access to the recently published GTEx data set (https://www.biorxiv.org/content/biorxiv/early/2016/09/09/074443.full.pdf; see discussion here https://www.biostars.org/p/283484/#283521) is quite hard for non-US institutions, I was wondering whether it is easier to just use another data set for my purpose.

Do you know of any data set that contains both genetic variants (coding and/or non-coding) and gene expression data? I want to develop an algorithm to derive causal relationships between a variant and the gene expressions. The GTEx data set seemed to be exactly what I needed. Is there anything similar available, e.g. for cancer? I know I can download both genetic variants and gene expressions from GDC, but these would probably have to undergo a lot of preprocessing, e.g. to select only a couple of genetic variants (which is beyond my biological expertise) or select only gene expression outliers as done in the GTEx data set.

Any suggestions are highly appreciated!

Best,

Cindy

gene expression variants causal relationship GTEx • 1.2k views
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