Why "Motile sperm domain-containing protein 2" has nothing to do with "sperm"?
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3.9 years ago
Farbod ★ 3.3k

Hi Biostars, (maybe my question is more biological than bioinformatic, of course I have asked it in other website but I could not find the answer, yet. If it is "OFFTOPIC" please remove it).

One of my rna-seq sequences has annotated with "motile sperm domain-containing protein 2".

I have searched the databases (e.g uniprot) and related GO terms but it seems that it has not any relation to "sperm" and/or "spermatogenesis".

Why is that?

My questions:

1- Does this gene has any relation to sperm/sperm motility? (please give me the reference)

2- If 1 = Negative, why there is a "motile sperm" in this gene's "name"?

NOTE: I have found it in brain samples!

~ Best

gene annotation biology • 1.3k views
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MOSPD2 function. As to why certain genes are named the way they are has its roots in historical observations. It appears to be highly expressed in immune cells.

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Hi @genomax, and thanks. So are you agree that MOSPD2 has noting to do with sperm?

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https://en.wikipedia.org/wiki/Major_sperm_protein. Domain (motile sperm domain, also called major sperm domain) found in these proteins (Major Sperm Protein) is conserved evolutionarily and the protein you mentioned above has this domain at position: 327 – 445. More information on this PFAM domain: http://www.genome.jp/dbget-bin/www_bget?pfam:Motile_Sperm and http://pfam.xfam.org/family/Motile_Sperm.

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Dear @cpad0112 Hi and Thanks. Can you clarify me that this gene has role in sperm swimming speed or not? what does having same/shared conserved domain mean here?

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Can you clarify me that this gene has role in sperm swimming speed or not?

Unless scientifically proven (by reproducible experiments and establish in models), it is not easy to assign a function to protein. Hence sharing a functional sequence motif doesn't imply the same function (non-functional unless proven - to be conservative)

what does having same/shared conserved domain mean here?

That is the observation at sequence level. One has to prove in lab.

To answer your question, it is unknown at this point whether it has role in sperm swimming speed or not, unless some publications (reproducible research) say so.

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[Grumble]I just answered this exact question on the biology stackexchange.

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Many gene names don't really make sense, especially if their name is derived from some homology with a certain protein domain.

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3.9 years ago

[Not really a bioinformatics question, but since I know the answer, here goes]

MSP (major sperm protein) was first identified in nematode sperm. It forms filaments that drive sperm motility (crawling, not swimming). The MSP domain is evolutionarily conserved in a variety of transmembrane proteins involved in vesicle fusion, trafficking, and cell signaling, and is not limited to sperm.

PM/email me if you want more info.

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