Predicting Disulfide Bonds For Proteins With Many Cysteine Residues.
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3.9 years ago
jscience • 0

I have a set of proteins which have a lot of cysteines (more than 20 in each). I have made homology models for these proteins but need to predict the disulfide bonds/connectivity. I tried using DISULFIND but it is unable to predict connectivity for sequences with more than 10 cysteines.

Has anyone encountered this problem before? What is the most accurate way to predict disulfide bonds for proteins which do not have crystal structures?

Disulfide bond Protein Structure Program • 1.1k views
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In which file format is your data, specifically?

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I have fasta files of the sequences and pdb files of the homology models (which were made with SwissModel).

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Okay, I know that Jmol can predict di-sulfide bonding, but I cannot comment on its accuracy. It allows you to load PDB files.

I have also used SwissModel to predict protein conformation.

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