Question: How is it possible that multiple proteins maps to single transcript ids ?
0
gravatar for jack
15 months ago by
jack750
Germany
jack750 wrote:

Hi all,

I've downloaded transcript mapping to PDB annotation from GENECODE

When I look at the table, i see that one transcript id maps to multiple proteins. I was pondering about the reason behind of it. Here are some examples:

                  V1   V2
1  ENST00000567584.1 1UJU
2  ENST00000567584.1 1WHA
3  ENST00000567584.1 1X5Q
4  ENST00000567584.1 2W4F
5  ENST00000569114.1 1UJU
6  ENST00000569114.1 1WHA
7  ENST00000569114.1 1X5Q
8  ENST00000569114.1 2W4F
9  ENST00000564122.1 1UJU
10 ENST00000564122.1 1WHA
ADD COMMENTlink modified 15 months ago by Istvan Albert ♦♦ 79k • written 15 months ago by jack750
0
gravatar for Hussain Ather
15 months ago by
Hussain Ather910
National Institutes of Health, Bethesda, MD
Hussain Ather910 wrote:

A single transcript can have multiple ORFs that can give rise to multiple protein sequences.

ADD COMMENTlink written 15 months ago by Hussain Ather910
0
gravatar for Istvan Albert
15 months ago by
Istvan Albert ♦♦ 79k
University Park, USA
Istvan Albert ♦♦ 79k wrote:

It helps to look up the definitions for each:

https://www.ensembl.org/Homo_sapiens/Transcript/Idhistory?t=ENST00000569114

https://www.ensembl.org/Homo_sapiens/Transcript/Idhistory?t=ENST00000567584

Note how in this case both are marked as "retired".

In summary the data mapping stores all mappings, even historical ones that are now obsolete.

ADD COMMENTlink written 15 months ago by Istvan Albert ♦♦ 79k

This problem should be addressed in next Ensembl release: C: Ensembl ID converter not working?

ADD REPLYlink written 15 months ago by genomax64k
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