Question: How is it possible that multiple proteins maps to single transcript ids ?
0
gravatar for jack
21 months ago by
jack790
Germany
jack790 wrote:

Hi all,

I've downloaded transcript mapping to PDB annotation from GENECODE

When I look at the table, i see that one transcript id maps to multiple proteins. I was pondering about the reason behind of it. Here are some examples:

                  V1   V2
1  ENST00000567584.1 1UJU
2  ENST00000567584.1 1WHA
3  ENST00000567584.1 1X5Q
4  ENST00000567584.1 2W4F
5  ENST00000569114.1 1UJU
6  ENST00000569114.1 1WHA
7  ENST00000569114.1 1X5Q
8  ENST00000569114.1 2W4F
9  ENST00000564122.1 1UJU
10 ENST00000564122.1 1WHA
ADD COMMENTlink modified 21 months ago by Istvan Albert ♦♦ 81k • written 21 months ago by jack790
0
gravatar for Hussain Ather
21 months ago by
Hussain Ather940
National Institutes of Health, Bethesda, MD
Hussain Ather940 wrote:

A single transcript can have multiple ORFs that can give rise to multiple protein sequences.

ADD COMMENTlink written 21 months ago by Hussain Ather940
0
gravatar for Istvan Albert
21 months ago by
Istvan Albert ♦♦ 81k
University Park, USA
Istvan Albert ♦♦ 81k wrote:

It helps to look up the definitions for each:

https://www.ensembl.org/Homo_sapiens/Transcript/Idhistory?t=ENST00000569114

https://www.ensembl.org/Homo_sapiens/Transcript/Idhistory?t=ENST00000567584

Note how in this case both are marked as "retired".

In summary the data mapping stores all mappings, even historical ones that are now obsolete.

ADD COMMENTlink written 21 months ago by Istvan Albert ♦♦ 81k

This problem should be addressed in next Ensembl release: C: Ensembl ID converter not working?

ADD REPLYlink written 21 months ago by genomax71k
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