I want to analyze the gTEX dataset, but I am not interested in the impact of genotypes on phenotypes (RNA-Seq data).
In the lastest release of the gTEX data, more than 170,000 cis eQTL have been detected. Therefore a large amount of variation can be accounted by genetic loci.
I was wondering if anyone considered normalizing transcripts abundance by the genotype of the donors? My aim would be to obtain a matrix of gene counts normalized by genotypes.
Thanks a lot for inputs!