Question: Base Recalibration with different dbSNPbuild
gravatar for jxk906
3 months ago by
jxk9060 wrote:

Hi, I am trying to clarify whether I can run BaseRecalibration (GATK) step using dbSNPbuild 144 on already calibrated bam files with different dbSNP build (138). I am not sure whether it is advisable or will give a drastic change in variation calling? If I could get an insight on this will be really helpful.


dbsnp gatk • 227 views
ADD COMMENTlink modified 12 weeks ago by Kevin Blighe14k • written 3 months ago by jxk9060
gravatar for Kevin Blighe
12 weeks ago by
Kevin Blighe14k
London / Brazil
Kevin Blighe14k wrote:

I'm not sure that anyone would have done this previously. My own recommendation would to re-analyse the data and then re-perform the BaseRecalibration.

Also, as this is GATK related, you will get a better and more rapid response on the GATK Support Forum


ADD COMMENTlink written 12 weeks ago by Kevin Blighe14k
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