The Tishkoff lab at the University of Pennsylvania is seeking candidates for postdoctoral positions. We are integrating genomic, transcriptomic, metagenomic, metabolomic, and epigenomic datasets generated from a large sample of ethnically diverse Africans. We use evolutionary, statistical, and population genetics approaches to understand the genetic architecture of a number of anthropometric, cardiovascular, metabolic, and immune related traits for which we have detailed phenotype data. We are also interested in inferring the demographic history of African populations, determining the genetic basis of adaptation during human evolutionary history, and characterizing the evolution of gene regulation in humans. We are applying functional genomics approaches to determine the impact of candidate causal variants on gene regulation and chromatin interaction. Candidates will have an opportunity to develop creative, independent projects. There will be opportunities to work together with an outstanding team of collaborators with expertise in statistical and population genetics theory and functional genomics methodology. The candidate will also have the opportunity to participate in a large NIH collaborative effort involving analysis of genome sequence data from over 100,000 participants.
The ideal functional genomics candidate would have expertise in using cutting edge techniques for characterizing gene regulation and chromatin structure (e.g. massively parallel reporter assays, chromosome conformation capture, DNA acetylation and methylation analyses). The ideal computational candidates will have skills in computer programming (PERL/Python/C++) and using statistical environments (R/MATLAB) as well as expertise in population genetics theory and/or quantitative analyses of complex traits. Experience with large genome-scale datasets is a plus. Candidates working with non-human or model organisms who want to obtain experience working with human data are encouraged to apply. Salaries are commensurate with qualifications and experience.
The Department of Genetics is centrally located at the School of Medicine within the UPenn campus and is within short walking distance to the Children's Hospital of Pennsylvania as well as the Departments of Biology, Computer Science, Bioengineering and Anthropology located on the main campus. Outstanding core facilities are available for high throughput sequencing, genotyping, and gene expression studies and for bioinformatics and computational biology analyses. UPenn has an interactive community of researchers with interests in evolutionary biology and genomics, the genetics of complex traits, and translational medicine. Philadelphia is a vibrant city with excellent cultural events and plenty of parks and hiking/biking trails. It is also centrally located between New York City and Washington DC, with easy access via a short train or bus ride.
Candidates should send curriculum vitae, a statement of interest, and contact information for three references via e-mail to Dr. Sarah Tishkoff, Departments of Genetics and Biology, University of Pennsylvania, tishkoff@pennmedicine.upenn.edu. The starting dates of positions are flexible.
Dr. Sarah Tishkoff Departments of Genetics and Biology University of Pennsylvania tishkoff@pennmedicine.upenn.edu http://www.med.upenn.edu/tishkoff/
