Closed:The input of pathway analysis based on GWAS

Question

[darklings]

Can I directly collect the lead SNPs identified from serval GWAS and meta-analysis for a specific disease as my candidate SNPs set and then use them to do the following gene mapping and pathway analysis?

However, in the pathway analysis publications and step-by-step guides I found, the SNPs they used are those genotyped from cases and controls in one or serval GWAS data and these large amounts of SNPs are filtered by QC. After that, the SNPs passed QC filters would be selected as candidate causal SNPs through some analysis...

Please give me some suggestions for doing pathway analysis based on some GWA studies or meta-analysis, thanks