I'm looking again at validating SNP calls (whole genome) and stumbled across this article
...in which the author(s) mention ...
...the number of novel non-synonymous SNPs can also be a very good indicator of the false positive rate. A study have shown that only 200–300 novel nonsynonymous SNPs should be identified per person by exome sequencing; a higher number would likely indicate a higher false-positive rate.
Reference "12" is Here ... however I didn't actually see that statistic (200-300) discussed.
I'm curious if anyone has used this method for validating SNPs? If so, is there a tool/protocol I can follow?