Question of " mutation correlation"

Question

[Qingyang Xiao]

Hello! Bioinformatic talents! I now have a basic question about genetic mutation. Can this variable be correlated with other data, like expression data? From my understanding, if the mutation data is quantifiable, then I can correlate with other omics data. Can you kindly give a comprehensive explanation please?

[Ram]

Qingyang Xiao why did you delete this post?

Answer 1

[Kevin Blighe]

It would be better to build a logistic regression model with the no mutation, heterozygote mutation, and homozygote mutation as the y variable categories, and gene expression as the predictor variable (x). For example:

glm(Mutation ~ Gene1)

You could alternatively build a linear regression model with gene expression as the y variable and the mutation categories as the predictors. For example:

lm(Gene1 ~ Mutation)