I have a question regarding ExAC.
I am trying to retrieve SNP with corresponding allele frequency for my own research. However, I noticed that ExAC dataset includes a fair amount of WES of phenotyped population including diabetes, Schizophrenia & Bipolar and Myocardial condition.
Wouldn't the SNP allele frequency be biased by these phenotyped population?
Also, ExAC states that they specifically excluded severe pediatric diseases. Why is this condition so special and has to be excluded?