I have been recently thinking to do some project of my own. I am getting more interested nowadays in bio-scripting and developing unique application with specific functionality. After brainstorming for long weeks I thought about one project, but dont know whether it's feasible or not. I dont have depth knowledge of moleculer level but idea is all I have got right now. Recently, in one lecture I heard about amino acid residues changes/mutation leads to diseases. For example, "Sickle cell anemia" an inherited blood disorder disease, where hemoblogin is defective. In normal Hemoglobin (Hb) where amino acid residue Glutamine is change into Valine at specific residues number.
My idea is finding all diseases which is caused by residues changes in specific amino acid chain (Polymer). I want to extract all information remotely or save locally in database for extending purpose.
User will enter diseases like (sickle cell anemia) in search query
Result will be a. Normal sequence/gene and their name when it wasn't defective/mutated
b. Two amino acid chain where one is normal and another is disorder/mutated
c. Highlighting disordered/changed amino acids and number of amino acid.
d. If possible displaying normal/defective structure of searched disorder diseases
e. Letting user change amino acid residues in a chain and if instantly matches to any records in database then show disordered/mutated disease.
f. Detail information about defective/mutated disease
g. Link ID to other databases if available
How can I find all genetic disorder diseases related due to change in amino acid? Which databases (NCBI, Swissprot, Uniprot, HGNC, OMIM) is best for my idea? Are there other databases where I can extract all disorder information at once so I can save them and identify residues changes? Are there already this kinds of project which functionality is same like mine?
At the same time, I am wondering whether my idea is feasible or not. To carry out this project what resources I have to go through or have prerequisite knowledge?
Thanks for your concern