Question: Mapping Protein Mutation to Genomic DNA
0
gravatar for gokce.ouz
5 months ago by
gokce.ouz30
Singapore
gokce.ouz30 wrote:

Hi,

We have specific protein mutations and we are searching for tools to map these protein mutations to the exact location on the genomic DNA.

Do you have any suggestions ?

Thanks

genomic mutation protein • 242 views
ADD COMMENTlink modified 5 months ago by Chris Miller20k • written 5 months ago by gokce.ouz30
1
gravatar for Chris Miller
5 months ago by
Chris Miller20k
Washington University in St. Louis, MO
Chris Miller20k wrote:

The short answer is you can't, because the amino acid code is degenerate. The long answer is, you can get close, if you're willing to make assumptions about the specific transcript being used and guess at which mutation caused a specific AA change, as there are several different possibilities.

There are many previous questions about this (here is one: https://www.biostars.org/p/15992/)

The best tool I'm aware of is Transvar

ADD COMMENTlink modified 5 months ago • written 5 months ago by Chris Miller20k

Thanks for the suggestions Chris Miller.

ADD REPLYlink written 5 months ago by gokce.ouz30
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