Question: Mapping Protein Mutation to Genomic DNA
0
gravatar for gokce.ouz
14 months ago by
gokce.ouz40
Singapore
gokce.ouz40 wrote:

Hi,

We have specific protein mutations and we are searching for tools to map these protein mutations to the exact location on the genomic DNA.

Do you have any suggestions ?

Thanks

genomic mutation protein • 550 views
ADD COMMENTlink modified 14 months ago by Chris Miller20k • written 14 months ago by gokce.ouz40
1
gravatar for Chris Miller
14 months ago by
Chris Miller20k
Washington University in St. Louis, MO
Chris Miller20k wrote:

The short answer is you can't, because the amino acid code is degenerate. The long answer is, you can get close, if you're willing to make assumptions about the specific transcript being used and guess at which mutation caused a specific AA change, as there are several different possibilities.

There are many previous questions about this (here is one: https://www.biostars.org/p/15992/)

The best tool I'm aware of is Transvar

ADD COMMENTlink modified 14 months ago • written 14 months ago by Chris Miller20k

Thanks for the suggestions Chris Miller.

ADD REPLYlink written 14 months ago by gokce.ouz40
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