Question: Mapping Protein Mutation to Genomic DNA
0
gravatar for gokce.ouz
19 months ago by
gokce.ouz50
Singapore
gokce.ouz50 wrote:

Hi,

We have specific protein mutations and we are searching for tools to map these protein mutations to the exact location on the genomic DNA.

Do you have any suggestions ?

Thanks

genomic mutation protein • 687 views
ADD COMMENTlink modified 19 months ago by Chris Miller21k • written 19 months ago by gokce.ouz50
1
gravatar for Chris Miller
19 months ago by
Chris Miller21k
Washington University in St. Louis, MO
Chris Miller21k wrote:

The short answer is you can't, because the amino acid code is degenerate. The long answer is, you can get close, if you're willing to make assumptions about the specific transcript being used and guess at which mutation caused a specific AA change, as there are several different possibilities.

There are many previous questions about this (here is one: https://www.biostars.org/p/15992/)

The best tool I'm aware of is Transvar

ADD COMMENTlink modified 19 months ago • written 19 months ago by Chris Miller21k

Thanks for the suggestions Chris Miller.

ADD REPLYlink written 19 months ago by gokce.ouz50
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