We are trying to get the copy number variation of the tumor only samples (from bam files) using the below workflow (not having paired normal samples)
and for preparing the PoN we plan to use the workflow in below link
Where do we download or get the normal samples (bam files) for creating the PoN (Panel of Normals)? If we have only one normal sample data (whole exome), can we use it instead of using more that one because the coverage is whole.
Can we use the normal exome data from this link https://github.com/genome/gms/wiki/HCC1395-WGS-Exome-RNA-Seq-Data.
Can we use the exomes from the the 1000 genomes website for preparing the PoN. http://www.internationalgenome.org/data-portal/sample
Thanks Dr. Prabhakar