Question: Looking for clinically validated anticancer drugs list
1
gravatar for elb
19 months ago by
elb160
Torino
elb160 wrote:

Hi guys, I have a list of genes and I would like to know if among my genes there are targets of known or at least clinically validated drugs in the sense that at least the drugs have to be in some phase of clinical validation. No computational predictions, no hypothesis but only clinical validity. Drugs validated in vivo will be ok. Do you have an idea about the available tools to achieve my goal?

Thank you in advance

ADD COMMENTlink modified 19 months ago by Denise - Open Targets5.0k • written 19 months ago by elb160

You may have already looked at a search with the terms (anticancer drug database). Several papers/db surface via google. You should list ones you don't like/have looked at so you don't get those same suggestions in answers/comments.

ADD REPLYlink modified 19 months ago • written 19 months ago by genomax71k

Thank you very much for your suggestion. The point is that there are many resources and it is hard to filter out what is not proper for your research. For this reason I was looking for someone already expert in the field. Anyway thank you again.

ADD REPLYlink written 19 months ago by elb160

Thanks for that clarification. While you wait for answers there should be enough leads for you to look through via the search I mentioned above.

ADD REPLYlink written 19 months ago by genomax71k

Of course I'm doing it.

ADD REPLYlink written 19 months ago by elb160
6
gravatar for Arnaud Ceol
19 months ago by
Arnaud Ceol840
Milan, Italy
Arnaud Ceol840 wrote:

You could have a look at the Therapeutic target database: https://db.idrblab.org/ttd/. I've used it in the past without any filter, but I've seen it is possible to search for target AND disease.

ADD COMMENTlink written 19 months ago by Arnaud Ceol840

Thank you very very much! Exactly what I need.

ADD REPLYlink written 19 months ago by elb160

If the answer resolved your question you should mark it as accepted.
Upvote|Bookmark|Accept

ADD REPLYlink modified 19 months ago • written 19 months ago by genomax71k

Done! Thank you to all

ADD REPLYlink written 19 months ago by elb160
1
gravatar for Denise - Open Targets
19 months ago by
UK, Hinxton, EMBL-EBI
Denise - Open Targets5.0k wrote:

You can use the batch search tool of Open Targets. Input your list of genes (either HGNC, UniProt IDs or Ensembl IDs) and get the drugs targeting those genes. You will get the drug (e.g. CELECOXIB), its clinical phase (e.g. IV), mechanism of action, and links to the original source of the data, i.e. ChEMBL. In addition to the drugs, you will see the diseases these targets are associated with, the pathways they are involved with and the interactions between them at the protein level. There is this quick animation showing how.

If your list of genes is not too long, you can use the Open Targets Platform instead and enter each gene on a one by one case basis. The data is the same as what you get from the batch search, the visualisations are slightly different. These are the drugs in clinical trials used as evidence for ITGAL in psoriosis.

ADD COMMENTlink written 19 months ago by Denise - Open Targets5.0k
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