19 months ago by
UK, Hinxton, EMBL-EBI
You can use the batch search tool of Open Targets. Input your list of genes (either HGNC, UniProt IDs or Ensembl IDs) and get the drugs targeting those genes. You will get the drug (e.g. CELECOXIB), its clinical phase (e.g. IV), mechanism of action, and links to the original source of the data, i.e. ChEMBL. In addition to the drugs, you will see the diseases these targets are associated with, the pathways they are involved with and the interactions between them at the protein level. There is this quick animation showing how.
If your list of genes is not too long, you can use the Open Targets Platform instead and enter each gene on a one by one case basis. The data is the same as what you get from the batch search, the visualisations are slightly different. These are the drugs in clinical trials used as evidence for ITGAL in psoriosis.