Question: CNV/LOH from RNAseq
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gravatar for j.f.gutierrez-marcos
20 months ago by
j.f.gutierrez-marcos0 wrote:

Could I use RNAseq data from healthy and tumour samples to determine chromosome abnormalities?

rna-seq • 770 views
ADD COMMENTlink modified 19 months ago by igor8.6k • written 20 months ago by j.f.gutierrez-marcos0

You could use RNA-seq to detect the outliers in gene expression : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4454687/

Regarding the molecular mechanisms that lead to "outlier" gene expression, these could be multiple : either a CNV (AMP) or a SV that bring a super-enhancer near that gene, that determines "super" high gene expression.

ADD REPLYlink written 20 months ago by Bogdan880
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gravatar for igor
19 months ago by
igor8.6k
United States
igor8.6k wrote:

I actually had a similar question earlier that may give you some ideas: CNV detection from RNA-seq data

ADD COMMENTlink written 19 months ago by igor8.6k
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