Question: CNV/LOH from RNAseq
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gravatar for j.f.gutierrez-marcos
9 months ago by
j.f.gutierrez-marcos0 wrote:

Could I use RNAseq data from healthy and tumour samples to determine chromosome abnormalities?

rna-seq • 416 views
ADD COMMENTlink modified 9 months ago by igor7.1k • written 9 months ago by j.f.gutierrez-marcos0

You could use RNA-seq to detect the outliers in gene expression : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4454687/

Regarding the molecular mechanisms that lead to "outlier" gene expression, these could be multiple : either a CNV (AMP) or a SV that bring a super-enhancer near that gene, that determines "super" high gene expression.

ADD REPLYlink written 9 months ago by Bogdan690
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gravatar for igor
9 months ago by
igor7.1k
United States
igor7.1k wrote:

I actually had a similar question earlier that may give you some ideas: CNV detection from RNA-seq data

ADD COMMENTlink written 9 months ago by igor7.1k
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