Question: From gene list to disease ontology
0
gravatar for archie
19 months ago by
archie90
India
archie90 wrote:

Dear all , I am working on network based gene expression analysis. Based on network topology measures, I have retrieved hub genes from various sub clusters. For specific biological interpretation, I want to check their importance in terms of their disease specificity. I explored Fundo available at http://fundo.nubic.northwestern.edu/ui/infer which is not working now.

I also tried to use DOSE http://www.bioconductor.org/packages/release/bioc/vignettes/DOSE/inst/doc/semanticAnalysis.html#dosim-function

But there is not any function to change from gene list to disease ontology .

Is there any other way to perform disease ontology based analysis of set of genes ?

Thank you in advance

Archana

ADD COMMENTlink written 19 months ago by archie90
1

Dear all,

I just found this link https://bioconductor.org/packages/devel/bioc/vignettes/DOSE/inst/doc/enrichmentAnalysis.html#enrichdo-function where gene disease association could be done by using enrichDO function . May be useful for those who are working in this area.

Thank you

ADD REPLYlink written 19 months ago by archie90

thanks for your updates.

ADD REPLYlink written 19 months ago by Guangchuang Yu2.2k
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