We are trying to establish a standard of sequencing coverage (depth) - CNV sliding window size relationship.
For example, Some researches have shown that CNV can be detected for 0.25 WGS sequencing depth and 50 kb window size.
My question is: If 0.25 septh - 50 kb window size is valid, can we in principle approximately infer that 0.5 depth - 25 kb window size has the same sensitivity (same sample, sample sample prep and sequencing protocol)
My underlying assumption is that the CNV detection sensitivity (significance) is depends on the amount of reads within the sliding window (0.2550 == 0.525).
Any comments are appreciated.