Salary: Upto £46241pa plus excellent benefits
Fixed-term until 31st March 2021
The NIHR Global Health Research Unit on Genomic Surveillance of Antimicrobial Resistance (AMR) aims to provide intelligent global surveillance of bacterial pathogens using whole genome sequencing (WGS) through appropriate sampling and analysis in sentinel surveillance sites within strategically relevant countries.
We are seeking an enthusiastic Bioinformatics Implementation Manager to facilitate transfer of expertise and ownership of microbial genomic data processing and interpretation in four sentinel laboratories in strategic locations; India, The Philippines, Colombia and Nigeria. Each laboratory has been chosen to represent a network of hospitals either actively or on the cusp of being involved in the surveillance of AMR within each country.
You will lead front-line bioinformatics method development and support for large scale sample processing / data QC and interpretation at The Centre for Genomic Pathogen Surveillance (CGPS) at The Wellcome Sanger Institute (WSI) to provide expertise in interpretation through easy-to-use data tools and analytics will enable each location to further develop local research agendas and to feed data into broader global monitoring of particular pathogens between sites through open access databases.
You should be intimate with pipelines for the processing of microbial genomic data, and have an enthusiasm for the operationalizing and delivery of data and interpretation via the web. Within CGPS, we develop user-friendly web applications for the delivery of genomic data, linked to relevant epidemiological information for interpretation. (see Microreact , WGSA , Epicollect5)
Working closely with the Laboratory Implementation Manager, and a team of genomic epidemiologists, bioinformaticians, post-doctoral scientists and software and web application developers you will manage and lead the operationalisation of data flow infrastructure in sentinel laboratories in LMICs. You will bring an enthusiasm for translational bioinformatics and lead the development of cross-facility training programmes, bioinformatics SOPs, QA and QC and data interpretation protocols for the genomic surveillance of AMR.
Essential Skills An expert in independently solving bioinformatics problems, as part of PhD work and on-the-job training. Good programming skills (Python, Perl, R) Proficiency in Unix/Linux operating system Experience with managing and processing next-generation sequencing data Experience with using compute cluster and batch queuing systems Strong grounding in genome biology Experience with genome assembly methodologies and pipelines Excellent interpersonal skills Attention to detail Highly developed problem solving skills Experience with using relational database systems
Other information The Wellcome Sanger Institute is a charitably funded research centre and committed to training the next generation of genome scientists. Focused on understanding the role of genetics in health and disease and a world leader in the genomic revolution, our mission is to use genome sequences to advance understanding of human and pathogen biology in order to improve human health. We aim to provide results that can be translated into diagnostics, treatments or therapies that reduce global health burdens. Our science is large-scale and organised into Programmes, led by our Faculty who conceive and deliver our science, and supported by our Scientific Operations teams responsible for all data production pipelines at the Institute. Our Campus: Set over 125 acres, the stunning and dynamic Wellcome Genome Campus is the biggest aggregate concentration of people in the world working on the common theme of Genomes and BioData. It brings together a diverse and extraordinary scientific community, committed to delivering life-changing science with the reach, scale and imagination to solve some of humanity’s greatest challenges. The Campus is a community of organisations working in genomic research, enterprise, education and discourse. It is home to some of the world's foremost institutes and organisations in genomics and computational biology, including the Wellcome Sanger Institute which is the largest organisation on Campus, the European Bioinformatics Institute (EMBL-EBI), Open Targets and Genomics England. Also located here is Connecting Science - its mission is to enable everyone to explore genomic science and its impact on research, health and society by drawing on the ground-breaking research taking place on the Campus. Genome Research Limited is an Equal Opportunity employer. As part of our commitment to gender equality and promoting women’s careers in science, we hold an Athena SWAN Bronze Award. We will consider all applicants without discrimination on grounds of disability, sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law.
Please include a covering letter and CV with your application.
Closing date for applications: 12 April 2018