Question: Difference between Gene co-expression network and Gene regulatory network
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gravatar for Mike
20 months ago by
Mike1.4k
UK
Mike1.4k wrote:

Hi All,

What are basic difference between Gene co-expression network and Gene regulatory network ? I want to build co-expression and regulatory network for a list of genes from RNAseq data, could you please suggest me tools for both type of networks.

Thanks

rna-seq gene • 1.0k views
ADD COMMENTlink written 20 months ago by Mike1.4k

The main difference is that gene co-expression is built using expression data (RNA) for each pair of genes which they have relationship, whereas gene regulatory network is collection of regulators (DNA, RNA, proteins) which regulates the expression. So if you have just RNASeq data, you should start wit building co-expression network. In R, there is well known and used package called WGCNA.

ADD REPLYlink modified 20 months ago • written 20 months ago by arta540
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