Question: GATK joint genotyping
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gravatar for win
19 months ago by
win810
India
win810 wrote:

Hi all, i am struggling a bit with preparing a cohort genome vcf file for joint genotyping using GATK.

I tried with 30 BAMs from 1000 genomes, and generated a single sample VCF for each, then used GATK CombineVariants and produced a "master" gVCF file.

This is not working during variant calling since it says the gVCF file is not valid.

Could someone please help in defining the right steps for generating a cohort gVCF file for use in GATK joint genotyping?

Thanks in advance.

ngs gatk • 911 views
ADD COMMENTlink written 19 months ago by win810

Which version of GATK? What were the commands you used? Did you read the documentation (e.g here, here and here)? Did you name your gVCF as file.g.vcf?

ADD REPLYlink written 19 months ago by h.mon27k
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