Super-enhacer identification with ATAC-Seq
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6.1 years ago
Venados ▴ 30

Hello Everyone!

Has anyone tried to identify super-enhancers by applying the ROSE algorithm to ATAC-Seq data?

Any thoughts on why this might or might not work.

Thanks a lot in advance for your comments and ideas!
super-enhancer ROSE ATAC-Seq • 2.2k views
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ROSE expects H3K27ac data, not open chromatin signals. Whatever result you'll get is not what the tool has been designed for.

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I see, in other words, ATAC-seq data doesn't correlate well with H3K27ac

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