Question: FoldX interaction energy and stability
gravatar for shyantani.maiti
2.7 years ago by
shyantani.maiti0 wrote:

Dear Sir/Madam, I have calculated the interaction energy between protein and another protein in a protein-protein complex using foldX. The value obtained is -0.13 and in another case I obtained the value of interaction energy as -8.

Interaction energy as per calculated by foldX ∆∆Gab = ∆Gab- (∆Ga + ∆Gb)

If I want to predict the stability from interaction energy by foldX, which value of interaction energy should I consider as stable. If the interaction energy decreases from -0.13 to -8, can I say that the binding affinity increases? It would be great if you please cite some references where I can use interaction energy to obtain the desired protein stability.

foldx interaction energy • 827 views
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